Sensory analysis of odor, taste, vision, via instrument for Pharmacy industry.

Instrumental organoleptic testing of pharmaceutical products

When formulating oral medicines, scientists face the challenges of masking the bitter taste of active principles or off-odors of some ingredients.

Indeed, odor and taste are key parameters in pharmaceutical oral forms since they determine palatability, patient acceptability and success on the market.

Our instrumental solutions for measuring and evaluating the odor and taste of medicines are designed to give rapid answer to organoleptic issues in pharmaceutical formulation and pharmaceutical product development:

  • • Taste masking efficiency testing
  • • Unpleasant odor masking evaluation
  • • Bitterness measurement of active principles and new chemical entities
  • • Taste matching placebo assessment

Examples of applications in sensory analysis of medicines

Using our chemical and sensory analysis instruments, a wide variety of applications on oral medicines and nutraceutics have been successfully achieved such as:

  • • Quantitative evaluation of the masking efficiency of various taste masking techniques such as addition of flavors or sweeteners, coating, encapsulation, polymer extrusion
  • • Determination of the bitterness intensity of active ingredients
  • • Comparison of the taste and bitterness level of brand and generic orally disintegrating tablets
  • • Quantification of the odor masking power of various coatings on tablets containing an active principle with a strong odor
  • • Optimization of taste matching placebo development for double blind clinical trials
  • • Assessment of odor quality and intensity of Omega-3 nutraceutics using the same scoring scale as a sensory panel
  • • Investigation of various food vehicles for masking the bitterness of a pediatric syrup
  • • Selection of the packaging type (plastic versus glass) that will best assure active ingredients stability over time

Advantages of instrumental sensory analysis in the pharmaceutical industry

  • • A global multi-sensory approach (odor, taste) by combined use of electronic nose and electronic tongue
  • • Reliable results produced from instrumental measurements that can be correlated with sensory panel evaluation
  • • A means to avoid unpleasant testing of bitter substances for sensory panel assessors
  • • No more safety issues linked to human testing
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